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PART I: General Information DATE PREPARED: October 26, 2001 Name: Steven Elliot Locke Office Address: Institute of Cybermedicine Home Address: Ten Deer Run, Wayland, MA 01778 E:Mail: steven_locke@hms.harvard.edu FAX: 801-340-6828 Place of Birth: Englewood, NJ Education: 1968 A.B. Cornell University Postdoctoral Training: 1971-1972 Daniel Alpern Research Fellow (neurochemistry), Columbia
University, College of Physicians and Surgeons, New York, NY Licensure and Certification: 1973 California License Academic Appointments: 1974-1977 Clinical Fellow in Psychiatry, Harvard Medical School Hospital or Affiliated Institution Appointments: 1973-1974 Assistant Attending Physician, University of California,
Berkeley, CA Other Professional Positions and Major Visiting Appointments: 1976-1980 Research Psychiatrist, Harvard University Health Service
1976-1977 Chief Resident, Outpatient Clinic, McLean Hospital Major Administrative Responsibilities: 1987-1989 Quality Assurance Coordinator, Department of Psychiatry,
Beth Israel Hospital Major Committee Assignments: Medical School/School of Dental Medicine: 1987-1990 AIDS Task Force, Department of Psychiatry, Harvard Medical
School.
1983-1987 Research Committee, Clinical Research Center, Beth Israel
Hospital Regional: 1990-1992 Corporate Health-Cost Research Alliance, Task Force on
Health System Reform Options (Steering Committee) National: 1983-1991 Scientific Advisory Council, Institute for the Advancement
of Health Professional Societies: 1973-1988 American Society for Applied Psychophysiology and Biofeedback
1977-1980 American Cancer Society, Massachusetts Division, Service
Committee, Task Force on Support Groups, Chairperson 1984-1987 Associate Editor, Biofeedback and Self-Regulation Awards and Honors: 1972 Columbia Presbyterian Medical Society Research Award
A. Narrative report of Research, Teaching, and Clinical Contributions My teaching centers around three areas: 1) patient-centered clinical computing and e-health, 2) the doctor-patient relationship and reflective medical practice, 3) behavioral medicine and the management of chronic medical illness. During the years 1989-1995, I served as Director of Medical Student Education for Psychiatry at Beth Israel Hospital/Beth Israel Deaconess Medical Center. In that capacity I was the course director as well as a tutor/instructor for Psychiatry 700M.J (Psychopathology), the Core Clerkship in Psychiatry, and advanced clerkship in Consultation-Liaison Psychiatry in the General Hospital (PS501M.1), and two electives in behavioral medicine. One of my innovative contributions to teaching in that setting was the acquisition and use of videotapes of feature films that contained illustrations of psychopathology (e.g., Ordinary People, The Fisher King, Death of a Salesman, etc.) to engage the student in the learning process. During the period from 1986-1995, the student evaluations for the core clerkship at Beth Israel improved considerably. Since 1996, I have served as a tutor in Doctor-Patient III for the Health Sciences and Technology academic society. In 1997, the course director and the HST Society Master asked me to serve as the Senior Fellow for HST in Patient-Doctor III. Since that time I have served in both roles and have participated in the regular Senior Fellow meetings with the course director as part of the course direction and oversight. My service on the Curriculum Committee for HST as well as the Educational Technology Subcommittee has permitted me to participate in educational reform and curricular innovation. In 1997, my proposal to the HST Curriculum Committee for the creation of a new elective course on applied clinical information technology was approved by the committee and since 1998, HST921, Information Technology in the Healthcare System of the Future, has attracted 25-35 graduate students each year. Students have registered from the various schools and departments of both Harvard and MIT, including, HMS, HSPH., KSG, HGSE, HBS (Harvard); Sloan, Biomedical Engineering, Computer Science, Media Lab, and others (MIT). The trans-faculty course includes lectures by Harvard and MIT faculty, guest lecturers from industry, and a design project in which interdisciplinary teams of students collaborate under supervision to design an IT application to solve a present or future health care problem. My research activities were for the first fifteen years of my career in the field of psychoneuroimmunology. In 1995, I changed fields and began to do research, teach, and publish in the area of clinical computing. My research focus since that time has been on the use of behavioral informatics and behavioral medicine to improve the medical and psychiatric care of patients with chronic medical illness. Since it was founded in 1998 to June, 2001, I have served as the Director of the Institute of Cybermedicine in the Harvard Medical School Department of Psychiatry. My clinical contributions have been in my role as a clinical chief of behavioral medicine at Harvard Vanguard where I have led a team of clinicians in the development of innovative, evidence-based mind/body medicine programs for the management of chronic medical conditions.
1976-1977 NIMH/GRSG PI 1980-1984 NCI/R23 (Young Investigator Award) PI 1983-1986 Institute for the Advancement of Health PI (Education) 1984-1985 NIMH/RO3 PI 1985-1986 The Kroc Foundation PI 1986 Astra Pharmaceutical Corporation PI (Education) 1988 The Fetzer Foundation PI 1991-1993 The Fetzer Institute PI 1991-1993 The Institute of Noetic Sciences PI 1990-1994 The Kettering Foundation PI 1994-1995 Pacific Bell PI 1995-1999 The Koop Institute Co-Investigator 1998-2001 Robert Wood Johnson Foundation PI 1998-2001 Harvard Pilgrim Health Care Foundation PI 1998-2003 National Institute of Mental Health Co-investigator 2001-2003 Robert Wood Johnson Foundation Co-investigator
A Controlled Clinical Trial of a Behavioral Medicine Program for Somatizing Medical Outpatients Identified by a Brief, Self-administered Screening Questionnaire (PI) Cost-effectiveness Study of a Behavioral Medicine Program for Somatizing Medical Outpatients (PI) Adjustment to Chronic Medical Illness: The Case of Cardiac Illness (Co-investigator) A World Wide Web-based System for Patient-Centered Management of Major Depression (PI) 1. Local contributions 1990 1991-1995 1993-1997 1998-
1980-1985 1980-1982 1996- 1979-1986 Advising Responsibilities: 1987- 1990-1993 2. Regional, National, and International Contributions 140 presentations including 6 post-graduate courses (director), 33 workshops, 3 keynote addresses, 61 invited lectures and grand rounds, in North America, Europe, Israel, Japan, and Asia. Leadership Positions 1981-1982 1982-1983 1985-1989 1990-1992 1993- 1994-1996 1994 1995-1997 1996-1998 2000 2001 2001
2001
1989 Nominee, S. Robert Stone Teaching Award, Beth Israel Hospital
1. HST921 Information Technology in the Healthcare System of the
Future (see Narrative) E. Report of Clinical Activities 1. Description of clinical practice: adult and geriatric psychiatry with subspecialty interest in primary care psychiatry and psychosomatic/behavioral medicine. Sites: Harvard Vanguard Medical Associates (multi-site, multi-specialty group practice) and private office, Wayland, MA. 2. Patient load: 10-15 patients per week (currently in part-time practice). Complexity: moderate. 3. Clinical contributions: a) innovative leadership at HVMA on diabetes disease management team where led effort to screen patients for depression and refer for treatment in stepped-care model; b) pioneered successful case-finding approaches for identifying high-cost, high utilizing, somatizing patients and enrolling them in an evidence-based, clinically and cost-effective behavioral medicine group program; 3) led clinical team that developed novel behavioral medicine programs for fibromyalgia, chronic fatigue, and headache at HVMA; 4) founded and led clinical biofeedback program at Beth Israel Hospital in the 1980s; 5) Pioneered the use of a computer-assisted interview to screen prospective blood donors for the risk of transmitting HIV with their blood donation, 1992; 6) Developed the Stress Disorders Program at Beth Israel Hospital in the 1980s. 4. Other relevant information: Who's Who in Medicine and Healthcare, 1997-; invited to serve on medical advisory boards or as a medical consultant: Health Dialog (disease management and behavioral health); Commonweal (behavioral oncology); Diabetex (disease management and behavioral health); Proctor & Gamble (compliance and adherence); Pfizer Health Solutions (disease management and behavioral health), Talisman, Ltd. (computer-assisted blood donor screening)
Original Articles 1. Locke SE, Cohen G, Dembiec D. The uptake of 3H-6,7-dihydroxytetrahydro-isoquinoline into sympathetic nerves, in vivo. J Pharmacol Exper Therap 1973;187:56-57. 2. Locke RK, Locke SE. Nerve blocks in the foot for the emergency physician. J Am Coll Emerg Phys 1976;5:698-702. 3. Locke SE, Kraus L, Lesserman J, Hurst MW, Heisel JS, Williams RM. Life change stress, psychiatric symptoms and natural killer cell activity. Psychosom Med 1984;46:441-453. 4. Hutner NL and Locke SE. Health locus of control: a potential moderator variable for the relationship between life stress and psychopathology. Psychother Psychosom 1984;186-194. 5. Heisel JS, Locke SE, Kraus LJ, Williams RM. Natural killer cell activity and MMPI scores of a cohort of college students. Amer J Psychiat 1986;143:1382-86. 6. Locke SE, Ransil BJ, Covino NA, Toczydlowski J, Lohse CM, Dvorak HF, Arndt KA, Frankel, FH. Failure of hypnotic suggestion to alter immune response to delayed-type hypersensitivity antigens. Ann NY Acad Sci 1987;496:745-49. 7. Jemmott JB III, Hellman C, McClelland DC, Locke SE, Kraus LJ, Williams RM, Valeri CR. Motivational syndromes associated with natural killer cell activity. J Behav Med 1990;13:53-74. 8. Locke SE, Fox BH. The impact of stress on the clinical presentation
of melanoma (discussion). Plastic Reconstruct Surg 1992;90:62-64. 11. Locke SE, Ransil BJ, Zachariae R, Molay F, Tollins K, Covino NA, Danforth D. Effect of hypnotic suggestion on the DTH response in a group of highly hypnotizable, physiologically responsive subjects under controlled conditions. J Amer Med Assoc 1994;272:47-52.
1. Locke SE, Dembiec D, Cohen G. In vivo inhibition of neuronal uptake of a dopamine-derived tetrahydroisoquinoline (TIQ) alkaloid by cocaine and by desmethylimipramine (DMI). Fed. Proc. 1973;32:526. 2. Locke SE, Heisel JS. The influence of stress and emotions on human immunity. Biofeedback and Self Regulation. 1977;2:320. 3. Locke SE, Heisel JS, Williams RM, Hurst MW. The effects of life change stress on the human immune response. Abstracts of Papers of 144th Meeting, Herschman A, ed. American Association Advancement of Science, Washington, DC, 1978;146. 4. Locke SE, Jemmott J, Kraus L, Siber G, Heisel JS, Williams RM. Stress, adaptation and altered human immune function. Proceedings, the 6th World Congress of the International College of Psychosomatic Medicine, Montreal, 1981. 5. Locke SE. Brain, behavior and immunity. Proceedings, 13th International Cancer Congress, Seattle, 1982. 6. Locke SE. Looking ahead: possible stress effects on immunity.
Gerontologist. 1982;22:204. 8. Locke SE. Behavioral modification of immune function. Abstracts of Papers of 154th Meeting, American Association Advancement of Science, Boston, MA, 1988;42. 9. Locke SE, Kowaloff H, Safran C, Slack WV, Cotton D, Hoff R, Popovsky M, McGuff J, Page P. Computer-based interview for screening blood donors for risk of HIV transmission. SCAMC Proceedings: Fourteenth Annual Symposium on Computer Applications in Medical Care. Los Alamitos, CA: IEEE Press, 1990;835-839. 10. Zachariae R, Locke SE. Effects of hypnotic suggestions on immune and inflammatory processes - experimental studies 1962-1994. Int J Clin Exper Hypnosis 1994;42:477.
1. Locke SE. Stress, adaptation and immunity: studies in humans. General Hospital Psychiatry 1982;4:49-58. 2. Locke SE, Kraus L. Modulation of natural killer cell activity by life stress and coping ability. In: Levy SM, ed. Biological Mediators of Behavior and Disease: Neoplasia. New York: Elsevier North Holland, 1982;3-28. 3. Locke SE. Stress, personality and cancer. In: Rosenbaum ER, ed. Can you prevent cancer? St. Louis: C.V. Mosby, 1983;213-222. 4. Berkman L, Borysenko J, Locke SE, Rogers M, Partridge A. Psychological determinants of immunologically mediated diseases. Advances 1983;1:27-31. 5. Jemmott JB III, Locke SE. Psychosocial factors, immunologic mediation, and human susceptibility to disease: How much do we know? Psychol Bull 1984;95:78-108. 6. Locke SE. Depression and immunity. Harvard Medical School Mental Health Letter. 1986;3:8. 7. Locke SE and Colligan D. The healing factor. In: Carlson R and Newman B, Eds. Issues and Trends in Health. St. Louis: C.V. Mosby;1987;29-37. 8. Locke SE, Gorman, JR. Behavior and immunity. In: Kaplan HI, Sadock BJ, eds. Comprehensive Textbook of Psychiatry, Fifth Edition. Baltimore: Williams and Wilkins;1989;1240-1249. 9. Gorman JR, Locke SE. Neural, endocrine and immune interactions. In: Kaplan HI, Sadock BJ, eds. Comprehensive Textbook of Psychiatry, Fifth Edition. Baltimore: Williams and Wilkins;1989;111-125. 10. Bergeron B, Locke SE. Courseware options for the Macintosh. M.D. Computing 1989;6:44-9. 11. Bergeron B, Locke SE. The Macintosh in medicine (editorial). M.D. Computing 1989;6: 3. 12. Bergeron B, Locke SE. Expert systems, medicine, and the Macintosh. M.D. Computing 1989;6:100-111. 13. Locke SE. Holism must face controlled trials (editorial). Medical Tribune, December 13, 1990. 14. Bergeron B, Locke SE. Microcomputer-based instrumentation systems. M.D. Computing 1990;7:178-184. 15. Bergeron B, Locke SE. Speech recognition as a user interface. M.D. Computing 1990;7:329-334. 16. Friedman R, Molay F, Locke SE. Statistical packages for the Macintosh. M.D. Computing 1992;9:325-331. 17. Locke SE. Immunity. In: Healing: Luc Bessette, ed. Beyond Suffering and Death, Quebec, Canada: Publications MNH; 1994;73-75. 18. Farrar DJ, Locke SE, Kantrowitz FG. Chronic fatigue syndrome I: etiology and pathogenesis. Behavioral Medicine 1995;21:5-16. 19. Kantrowitz FG, Farrar DJ, Locke SE. Chronic fatigue syndrome II: treatment and future research. Behavioral Medicine 1995;21:17-24. 20. Locke SE and Rezza MEH. Computer-based education for patients and professionals. M.D. Computing 1996;13:10-48, 102. 21. Locke SE and Rezza MEH. Computer-based education for patients and professionals. In: Miller MJ, Hammond K, Hile M, editors. Mental Health Computing. New York: Springer-Verlag (1996) 22. Locke SE and Larsson KM. Clinical Presentation, Screening, and Treatment of Somatization in Primary Care Settings. In: Primary Care Meets Mental Health: Tools for the 21st Century. Haber JD, Mitchell GE, eds. Tiburon, CA: CentraLink Publications, 1997. Books 1. Locke SE, Hornig-Rohan M, editors. Mind and Immunity: Behavioral Immunology (1976-1982). New York: Institute for the Advancement of Health, 1983. Annotated bibliography. 2. Locke SE, Ader R, Besedovsky H, Hall NR, Solomon GF, Strom T, editors. Foundations of Psychoneuroimmunology. Hawthorne, NY: Aldine Publishing Co, 1985. 3. Hornig-Rohan M, Locke SE, editors. Psychological and Behavioral Treatments for Medical Disorders, Vol. I: Psychological and Behavioral Treatment of Disorders of the Heart and Blood Vessels. New York: Institute for the Advancement of Health, 1985. Annotated bibliography. 4. Locke SE, editor. Psychological and Behavioral Treatments for Medical Disorders, Vol. II: Disorders Associated with Immune Function. New York: Institute for the Advancement of Health, 1986. Annotated bibliography. 5. Locke SE, Colligan D. The Healer Within. New York: E.P. Dutton, 1986;New American Library, 1987, 1990. (Spanish, Italian, Japanese, German editions) 6. Pelletier KR, Joss JE, Locke SE. In Pursuit of Wellness, Volume 7: Personal Efficacy - A Research Database for the Clinical Application of Self-Efficacy in Mental Health. Sacramento, CA: State of California, 1992.
1. Locke SE. Medical therapy of gallstone: ethical aspects. New Engl J Med 1973;289:1371. 2. Locke SE. Effect of gluten in dermatitis herpetiformis -- implications for psychosomatic medicine. New Engl J Med 1983;309:315. 3. Green M, Locke SE. The immune system and its control: a possible
model in herpesvirus infections. J Clin Psychopharmacol 1988;8:68.
1. Blander J, Bergeron B, Sands D, Locke S. Course syllabus. Information Technology in the Healthcare System of the Future (HST921, 923), Harvard Medical School, 1999, 2000, 2001.
1. Locke SE, Kowaloff H, Safran C,
Slack WV, Cotton D, Hoff R, Popovsky M, McGuff J, Page P. Interactive
Interview to Assess Prospective Blood Donors' Risk of Transmitting
HIV with the Donation. Center for Clinical Computing, 1992. Resulting
publication in JAMA led to a commercial company, Talisman LLC, obtaining
an NHLBI SBIR grant and developing a commercial product to screen
blood donors using our computer-assisted approach. |
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